Some Studies on Lumpy Skin Disease Virus

Document Type : Scientific and Research

Authors

Agriculture Research Center, Animal Health Research Institute, Dokki, Giza, Egypt

Abstract

 Lumpy skin disease virus (LSDV) of cattle has been present in Egypt since 1988 which causes severe economic loses. An effort to eradicate this virus which has been carried out by vaccination has showed no great success. This research was performed as a trial to improve LSDV situation in Egypt using data obtained from affected farms in Sharquia Governorate. Virological studies confirmed the presence of LSDV in farms under study, while pathological investigations give deep sight about the pathogenesis and pathological effect of the disease using recent pathological techniques. The advances in pathology make this branch able to diagnose all diseases by more accurate and nondoubtful manner, with lower costs compared to egg inoculation, Polymerase Chain Reaction (PCR) or serological approaches. The pathological examination showed diagnostic findings as vasculitis, necrosis which seen in all cell kinds in the affected area and all skin layers, cellular infiltration, thrombosis with necrosis of smooth muscles of blood vessels, endothelial cell damages, along with the presence of intracytoplasmic and intranuclear viral inclusion bodies, in addition to positive immunofluorescence. Agar Gel Precipitation as well showed strong line of precipitate. It is presumptive that LSDV present in Egypt is of high virulence, as it causes severe skin lesions. 

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