Biochemical and cytogenetic Investigations into the effects of Enrofloxacin in rats

Document Type : Scientific and Research

Authors

1 Animal Health research Institute. Biochemistry Department Dokki

2 Animal Health research Institute. Biochemistry Department EL-Mansoura

Abstract

Oral administration of enrofloxacin at doses of 7.5 and 10mg for 30 successive days into mature rats significantly increased the frequencies and percentage of micro nucleated polychromatic erythrocytes (MPCEs) and ratio of polychromatic erythrocytes normochrotic erythrocytes ( PCE / NCE) was recorded.
The effect of enrofloxacin on body weight was studied in 2 groups of 10 mature rats each was orally administered by the tested drug at a dose of 7.5 and 10 mg/ 100gm.b..wt. for 30successiundays. Enrofloxacin showed insignificant increase in bodyweight of the rats at the doses. The tested drug significantly increased the activities of serum Aspartate amino transaminase(AST), Alanine amino transaminase (ALT) and the level of urea, but decreased the alkaline phosphatase (AP) activity and level of total protein 

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