Role of stem cells in decreasing renal failure in rats

Document Type : Scientific and Research

Authors

1 GEBRISadat University. Egypt

2 Biochemistry dept, GEBRISadat University. Egypt

3 Biochemistry dept., GEBRSadat University, Egypt

4 Experimental Biology dept., faculty of scienceAl-Azhar University, Cairo, Egypt

Abstract

Stem cells are homogenous cells able-to-proliferate and differentiate producing almost all types of cells. They can yield a great number of differentiated functional cells creating the tissue after hurt. Stem cell therapy is a recent type of intervention strategy that is introduced-to-treat-a-specific-illness. Renal failure is one of the greatest common reasons of morbidity-and-mortality-all-over-the-world. Treatment options of chronic renal failure (CRF) mainly involve renal transplantation and blood dialysis. Kidney transplantation is limited by shortage of donors while dialysis is-associated---with-- several-socioeconomic-problems-for-the-patients.-In this study we tried to estimate the use of stem cells for antagonizing induced renal failure via apoptotic parameters. The animals were classified into five groups which received chemotherapeutic drug (cisplatin) to induce kidney damage, tissue and blood samples were collected. The oxidative content measured by glutathione. The serum urea, creatinine and IL18 biomarkers levels were decreased significantly. This confirms that under the conditions of this study, stem cells can heal the renal damage made by cisplatin in rats. 

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