Ameliorating Effect of Garden cress on Diabetic Rats

Document Type : Scientific and Research

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Biological Sciences Department, College of Science and Art, Al-Qassim University, Saudi Arabia

Abstract

The aim of this investigation was to determine histopathological changes and some biochemical activities of two concentrations of Garden cress (Lepidium sativum L.) on normal and diabetic rats for successive days . Forty mature rats of body weight - gm ) were divided into 4 equal groups rats each.(G1) control ,(G2) diabetic control group injected intrapretonial by alloxan in a dose mg/kg. b.wt ,(G3& G4 ) diabetic rats fed on basal diet mixed with 1% & dried Garden cress (Lepidium sativum L.) respectively for 30 successive days. Blood samples were collected to separate serum to determine some biochemical parameters , some oxidative markers , relative organs weights and histopathology of kidney and pancreas were conducted at the end of the experiment . Results revealed that there were a significant decrease of serum levels of AST, ALT, ALP, cholesterol, triglyceride ,urea and glucose as well as MDA than diabetic control groups, on the other hand result showed no effect on albumin ,globulin and A/G ratio. While catalase enzyme activity showed a significant increase than control diabetic rats . The relative organs weight in (G3)and (G4) returned toward normal values. Conclusively , feeding of Garden cress at both concentrations for diabetic rat had a beneficial practical tool to minimize the effect of diabetes without any adverse effect on metabolic parameters and organs weight of rats.

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