Cytogenetic, Fertility and Pathological Studies Organophosphorus Insecticide of (Profenofose) on Male Rats.

Document Type : Scientific and Research

Authors

1 Chemistry Department, Animal Health Research Institute,

2 Chemistry Department, Animal Health Research Institute

3 Chemistry Department, Animal Health Research Institute, Dokki

Abstract

Oral administration of profenofose for 65 days in a dose of 1/10 and 1/100 LD50, respectively, significantly increase in the percentage of micronucleated polychromatic erythrocytes (MPCE), ratio of polychromatic erythroctes to normal chromatic erythrocytes (PCE/NCE). The PCE/NCE ratio used as a measure for red blood cell proliferation which gave a sign of toxicity or damage of some organs of the body. Also, a significant decrease in weight of testis than the control except at high dose which cause an increase in testis weigh. Although accessory glands (S.V., prostate and epididymis) showed variationi in weights than the control group. The sperm concentration and percentage of motility were decreased, although sperm abnormalities was increased which characterized by coiled tail and headless. The tested pesticide significantly increased the activities of serum AST, ALT and AP and the level of cholesterol, testosterone, bilirubin, while total protein, testosterone and creatinine significantly decreased.The treated rats with profenofos showed congestion, haemorrhage focal area of necrosis and lymphocytic mononuclear cell infiltration in liver and kidney. The spleen was hyperplastic with degeneration of thewall of some blood vessels. Severe degeneration and necrosis of the spermatic cells of the semineferous tubules in testis. Histopathological changes in different organs appeared to be dose dependent, with damage increase in the high doses. 

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