Synthesis and Identification of Chiral open-chain sugar-derived nitrones and their 1,3-Dipolar Cycloaddition with maleimide and maleic acid

Document Type : Scientific and Research

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College of Health and Medical Technology, Baghdad, IRAQ

Abstract

The chiral open-chain sugar-derived nitrones (a,b) were prepared in a pure form. N-Sugar-derived isoxazolidines (2a,b-3a,b)) were synthesized regiospecifically by 1,3-dipolar cycloaddition reaction of a nitrone (a,b) with maleimide and maleic acid. N-sugar-derived isoxazolidine (3a) showed high activity against staphylococcus aurous, and Escherichia coli and complete inhibition of growth against pathogenic fungi candida albicans and microsporum gypseum 

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