Protective effect of Cicer arietinum on infertility of male rats induced by gibrillic acid

Document Type : Scientific and Research

Authors

Biochem.Toxicol.& Feed Deff. Dept., AHRI, Dokki, Giza.

Abstract

The present study was carried out to elucidate the effect of Cicer arietinum (chick pea) on gibrillic acid (GA3) induced infertility as well as some serum parameters in male rats.

A total of forty adult male Albino rats (150-180 g) were used in this study. Rats were equally divided into 4 groups. Group one (1st) was kept as a control negative( –ve) and fed on basal diet only, while second (2nd) group fed on basal diet mixed with GA3 at concentration of 1g/ 100 kg ration as control positive(+ve). On other hand, third (3rd) group was fed on basal diet mixed with chick pea at conc. 5% and forth (4th) group was fed on basal diet mixed with both chick pea (5%) and GA3 (1 g / 100 kg. ration) for 65 successive days.

At the end of the experimental period, blood samples were collected from each rat for biochemical analysis. Rats were sacrificed for studying the sexual organs weight and epididymal sperm characters.

Rats fed on ration mixed with GA3 ,showed significant increase in serum levels of AST, ALT,AP, urea, creatinine, total cholesterol and sperm abnormalities; while the levels of serum total protein , albumin , globulin, testosterone and weight of sexual organs decreased significantly as compared with corresponding values of the controls (group one).
Rats fed on ration mixed with combination of chick pea and GA3 were significantly altered the tested parameters directed toward normal as compared with control positive (+ve) group.

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