Comparative study between steroidal and non- steroidal compound in rats

Document Type : Scientific and Research

Authors

1 Animal Health Research Institute, Chemistry Dept., Agric. Res.Center, Giza Egypt

2 Planing general manager in Kahira Pharmaceutical Company

3 Animal Health Research Institute El-Mansoura

Abstract

Comparative effects of non steroidal (Ibuprofen) and steroidal (dexamethazon) compound in rats were studied. A total of 60 male albino rats, about 130_150 grams were used and classified into 3 groups. The 1st.group injected distilled water intramuscularly and left as a control. The 2nd and 3rdgroup were injected Ibuprofen and dexamethazon at a dose of 0.9 mg and 0.8 mg/100gm b. wt. intramuscularly respectively for 5 consecutive days. The samples were taken after 1,7,15 and 45 days after stopping injection.
The results revealed that, ibuprofen and dexamethasone induced significant decrease in haemoglobin, red blood cells, total leucocytic count and lymphocytes beside total protein, albumin and globulin. On the other hand, significant increase neutrophil, ALT, AST,ALP, urea , creatinine, total lipid, cholesterol ,triglyceride A/G ratio, glucose and liver glycogen in tissue.
Our results indicated that Ibuprofen and dexamethazon caused dysfunction in blood picture, liver and kidney functions in rats. The study was showing the pathogenesis of Ibuprofen or dexamethazon which could be poisonous in therapeutic doses in rodents. 

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